Table 2. Results of meta-analysis comparison of LESS-N and CL-N two groups and LESS-RN and CL-RN two groups.
| Perioperative outcomes | Studies, number | LESS-N/LESS-RN patients, number | CL-N/CL-RN patients, number | WMD/OR (95% CI) | P-value | Study heterogeneity | |||
|---|---|---|---|---|---|---|---|---|---|
| X2 | df | I2, % | P-value | ||||||
| Perioperative outcomes for LESS-N and CL-N | |||||||||
| Operation time, min | 9 | 233 | 335 | 0.404 (0.226, 0.581) | 0.000 | 17.53 | 9 | 48.7 | 0.041 |
| EBL, ml | 7 | 210 | 248 | −0.214 (−0.516, 0.088) | 0.165 | 15.06 | 7 | 53.5 | 0.035 |
| Postoperative day of oral intake, d | 5 | 100 | 141 | −0.256 (−0.847, 0.335) | 0.397 | 4.83 | 2 | 58.6 | 0.089 |
| Length of stay, d | 9 | 252 | 352 | −0.319 (−0.615, −0.023) | 0.034 | 23.90 | 9 | 62.3 | 0.004 |
| VAS | 7 | 210 | 251 | −0.892 (−1.223, −0.561) | 0.000 | 16.84 | 7 | 58.4 | 0.018 |
| Analgesic requirement, mg | 3 | 70 | 93 | −0.550 (−0.870, −0.229) | 0.001 | 2.31 | 2 | 13.5 | 0.315 |
| Conversion rate | 9 | 235 | 377 | 11.685 (0.617, 4.606) | 0.309 | 4.22 | 4 | 5.2 | 0.377 |
| Perioperative complications | 8 | 156 | 195 | 11.742 (0.932, 3.254) | 0.082 | 9.39 | 8 | 14.8 | 0.310 |
| Intraoperative complications | 5 | 176 | 284 | 11.537 (0.585, 4.036) | 0.383 | 1.42 | 3 | 0.0 | 0.701 |
| Postoperative complications | 6 | 186 | 294 | 11.353 (0.817, 2.241) | 0.240 | 1.55 | 5 | 0.0 | 0.907 |
| Minor complications | 5 | 166 | 274 | 11.250 (0.722, 2.163) | 0.426 | 0.26 | 4 | 0.0 | 0.992 |
| Major complications | 5 | 166 | 274 | 12.132 (0.587, 7.740) | 0.250 | 1.45 | 2 | 0.0 | 0.483 |
| Perioperative outcomes for LESS-RN and CL-RN | |||||||||
| Operation time, min | 7 | 136 | 167 | 0.527 (0.120, 0.934) | 0.011 | 16.58 | 6 | 63.8 | 0.011 |
| EBL, ml | 6 | 126 | 152 | −0.234 (−0.594, 0.127) | 0.204 | 10.46 | 5 | 52.2 | 0.063 |
| Postoperative day of oral intake, d | 5 | 100 | 141 | −0.256 (−0.847, 0.335) | 0.397 | 4.83 | 2 | 58.6 | 0.089 |
| Length of stay, d | 7 | 155 | 184 | −0.390 (−0.759, −0.020) | 0.039 | 16.12 | 6 | 62.8 | 0.013 |
| VAS | 6 | 126 | 155 | −1.065 (−1.322, −0.808) | 0.000 | 4.53 | 5 | 0.0 | 0.475 |
| Analgesic requirement, mg | 3 | 70 | 93 | −0.550 (−0.870, −0.229) | 0.001 | 2.31 | 2 | 13.5 | 0.315 |
| Conversion rate | 7 | 143 | 225 | 14.209 (0.916, 19.346) | 0.065 | 1.91 | 2 | 0.0 | 0.385 |
| Perioperative complications | 8 | 151 | 179 | 11.412 (0.728, 2.740) | 0.308 | 4.76 | 7 | 0.0 | 0.690 |
| Intraoperative complications | 3 | 84 | 132 | 11.602 (0.364, 7.037) | 0.533 | 1.34 | 1 | 25.4 | 0.247 |
| Postoperative complications | 4 | 94 | 142 | 11.408 (0.598, 3.316) | 0.434 | 1.06 | 3 | 0.0 | 0.788 |
Abbreviations: CL-RN, conventional laparoscopic RN; df, degree of freedom; LESS-RN, laparoscopic single-site RN; WMD/OR, weighted mean difference/odds ratio.
1Odds ratio.