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. 2019 Aug 5;12:6145–6156. doi: 10.2147/OTT.S209784

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© 2019 Zheng et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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LINC00673 induced proliferation and tumor growth in vitro and in vivo.

Notes: (A) Knockdown of LINC0063 in OVCAR3 and HO8910 cells transfected with lentivirus. (B and C) Silencing of LINC00673 suppressed proliferation and increased cell apoptosis in OVCAR3 and HO8910 cells, while overexpression of LINC00673 promoted cell growth and reduced the percentage of apoptotic A2780 cells. Each experiment was repeated in triplicate. (D) Tumor growth in the KD group was significantly slower than that in the NC group, and the growth curves showed a widening gap between the two groups. (E and F) Tumor volumes in the KD and NC groups. (G) The knockdown efficiency of LINC00673 in vivo was verified by qRT-PCR. (H) Tumor weight in the KD group was significantly decreased compared with the NC group. The results are shown as the means ± SD; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001; Student’s t-test.

Abbreviations: KD, LINC00673-knockdown lentivirus cells; NC, LINC00673-negative control lentivirus cells; OE, LINC00673-overexpression lentivirus cells; Vector, LINC00673-vector lentivirus cells.