Table 3.
Multivariate analysis of prognostic factors in the SEER cohort
| Parameter | HR (95% CI) | P-value |
|---|---|---|
| Age, years | ||
| ≤60 | 1 | |
| >60 | 1.41 (1.09–1.83) | 0.009 |
| Sex | ||
| Male | 1 | |
| Female | 0.80 (0.62–1.04) | 0.090 |
| Location | ||
| Head | 1 | |
| Body and Tail | 0.57 (0.42–0.77) | <0.001 |
| Other | 0.83 (0.58–0.33) | 0.328 |
| Histologic grade* | ||
| I | 1 | |
| II | 1.50 (1.08–2.08) | 0.017 |
| III or IV | 4.47 (3.30–6.50) | <0.001 |
| Stage (AJCC 7th edition) | ||
| I | 1 | |
| II | 1.58 (0.97–2.59) | 0.068 |
| III | 2.52 (1.18–5.40) | 0.017 |
| IV | 4.57 (2.79–7.53) | <0.001 |
| Size (mm) | ||
| <34.5 | 1 | |
| >34.5 | 1.72 (1.26–2.35) | 0.001 |
| LNR | ||
| 0 | 1 | |
| <0.33 | 1.14 (0.79–1.65) | 0.448 |
| >0.33 | 1.45 (1.02–2.06) | 0.037 |
Notes: *Histologic grade assessed by tissue differentiation based on HE staining. Abbreviations: CI, confidence interval; HR, hazard ratio; AJCC, American Joint Committee on Cancer; ENETS, European Neuroendocrine Tumor Society.