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. 2019 Aug 5;11:7369–7376. doi: 10.2147/CMAR.S211020

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© 2019 Li et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Expression of hsa_circ_0085616 in the MHCC 97L cell line was downregulated by siRNA. (A) MHCC 97L cells transfected with si-hsa_circ_0085616 had significantly decreased expression of hsa_circ_0085616 compared with the negative control. (B) The proliferation of 97L cells decreased when cells were transfected with si-hsa_circ_0085616. (C) The transwell assay showed that the migration and invasion of 97L cells were suppressed when cells were transfected with si-hsa_circ_0085616. (D) Flow cytometry results showed that more 97L transfected cells stayed at G1/G0 stage than S and G2/M stage. (E) Flow cytometry results showed that 97L cell apoptosis increased after transfection with siRNA. **p<0.01 and ****p<0.0001 compared to controls.

Abbreviation: NC, Negative control.