Figure 1.

Landscape of genomic alterations in HCC. A, Comparison of the clinical characteristics of the MSK HCC (N = 127) and the TCGA HCC cohorts (N = 196). B, The most common genomic alterations in liver cancer listed in order of frequency. C, Oncoprint of commonly altered genes. Tumors are split into three groups (WNT/β-catenin pathway altered, TP53 altered, and other). Genes were grouped by pathway/function, and select clinicopathologic parameters are shown for all tumors. Clinicopathologic features and mutations were color coded by type. VUS, variant of unknown significance.