Table 1.
Baseline Demographic and Clinical Characteristics for All Randomized and Study Completing Participantsa
| Randomized | Completed 6-month follow-up | ||||
|---|---|---|---|---|---|
| Overall (N = 27) | Atorvastatin (n = 14) | Placebo (n = 13) | Atorvastatin (n = 9) | Placebo (n = 6) | |
| Age (years) | 26.8 ± 6.2 | 26.6 ± 5.7 | 26.9 ± 6.9 | 28.0 ± 5.7 | 26.4 ± 7.5 |
| Sex (male), n (%) | 14 (51.9%) | 6 (42.9%) | 8 (61.5%) | 3 (33.3%) | 3 (50.0%) |
| Diagnosis age (years) | 7.2 ± 5.2 | 8.0 ± 4.6 | 6.2 ± 5.8 | 7.8 ± 3.9 | 5.0 ± 3.2 |
| Years cancer free (years) | 17.1 ± 7.3 | 16.1 ± 6.6 | 18.2 ± 8.1 | 17.9 ± 7.3 | 18.4 ± 7.6 |
| Diagnosis (n, ALL/NHL) | 19/8 | 10/4 | 9/4 | 6/3 | 5/1 |
| Treatment, n (%) | |||||
| Chemotherapy | 17 (63.0%) | 9 (64.3%) | 8 (61.5%) | 5 (55.6%) | 4 (66.7%) |
| Chemotherapy + radiation | 9 (33.3%) | 4 (28.6%) | 5 (38.5%) | 4 (44.4%) | 2 (33.3%) |
| BMT | 1 (3.7%) | 1 (7.1%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Weight (kg) | 88.3 ± 22.1 | 89.5 ± 22.8 | 87.0 ± 22.1 | 91.6 ± 21.5 | 72.5 ± 12.3 |
| BMI (kg/m2) | 31.0 ± 7.5 | 31.8 ± 7.9 | 30.1 ± 7.3 | 33.6 ± 7.9 | 25.4 ± 4.8 |
| Systolic BP (mmHg) | 124 ± 15 | 119 ± 13 | 129 ± 14 | 119 ± 15 | 121 ± 14 |
| Diastolic BP (mmHg) | 70 ± 12 | 68 ± 10 | 72 ± 14 | 67 ± 12 | 69 ± 12 |
| Fasting glucose (mg/dL) | 80 ± 17 | 84 ± 11 | 75 ± 21 | 84 ± 11 | 70 ± 31 |
| TC (mg/dL) | 174 ± 35 | 176 ± 41 | 172 ± 29 | 191 ± 33 | 167 ± 27 |
| LDL (mg/dL) | 104 ± 32 | 105 ± 34 | 103 ± 30 | 119 ± 25 | 98 ± 36 |
| VLDL (mg/dL) | 23 ± 9 | 25 ± 10 | 21 ± 8 | 28 ± 9 | 19 ± 7 |
| HDL (mg/dL) | 47 ± 11 | 45 ± 10 | 49 ± 12 | 43 ± 9 | 51 ± 14 |
| Triglycerides (mg/dL) | 116 ± 45 | 12 ± 48.0 | 103 ± 39 | 140 ± 43 | 94 ± 33 |
| TC/HDL ratio | 3.9 ± 1.1 | 4.0 ± 1.2 | 3.7 ± 1.1 | 4.5 ± 1.0 | 3.6 ± 1.3 |
| ALT (U/L) | 39 ± 16 | 37 ± 15 | 41 ± 18 | 35 ± 12 | 28 ± 8 |
| AST (U/L) | 30 ± 10 | 27 ± 12 | 32 ± 9 | 27 ± 9 | 25 ± 2 |
| CK (U/L) | 107 ± 54 | 104 ± 62 | 111 ± 48 | 94 ± 55 | 100 ± 16 |
a
Values are raw means ± SDs, unless otherwise indicated.
ALL, acute lymphoblastic leukemia; ALT, alanine transaminase; AST, aspartate aminotransferase; CK, creatine kinase; BMI, body mass index; BMT, bone marrow transplant; BP, blood pressure; HDL, high-density lipoproteins; LDL, low-density lipoproteins; NHL, non-Hodgkin's lymphoma; TC, total cholesterol; VLDL, very low-density lipoproteins; SD, standard deviation.