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. Author manuscript; available in PMC: 2020 Jul 25.
Published in final edited form as: Cell. 2019 Jun 27;178(3):536–551.e14. doi: 10.1016/j.cell.2019.05.056

Figure 5. LANDO mitigates tau hyperphosphorylation.

Figure 5.

A. and B. Representative images showing phosphorylation of Tau at S202/T205 in the hippocampus (A) and cortex (B) of 4m-old LANDO-deficient 5xFAD mice. Scale bars, 100μm for A, 30μm for B. Upper images are combined DAPI and anti-pTau, lower are anti-pTau only.

C. and D. Quantification of phospho-tau in the hippocampus (C) and cortex (D) of the indicated 5xFAD genotypes at 4m of age. The MFI of phospho-tau staining for each genotype is shown as relative to Wt, 5xFAD littermates as described for Iba1 staining (See Fig. 4 legend). Each point represents an individual mouse.

Data are represented as mean ± SEM. Significance was calculated using Student’s t-test. *p<0.05, **p<0.01, ***p<0.001.