Skip to main content
. Author manuscript; available in PMC: 2019 Aug 10.
Published in final edited form as: Nat Neurosci. 2016 Mar 14;19(4):571–577. doi: 10.1038/nn.4267

Figure 2.

Figure 2

The genomic position and coding consequences of 16 SETD1A LoF variants observed in the schizophrenia exome meta-analysis, the DDD study and the SiSU project. Variants discovered in patients with schizophrenia are plotted above the gene and those discovered in individuals with other neurodevelopmental disorders (from DDD and SISu) are plotted below. Each variant is colored according to its mode of inheritance. All LoF variants appeared before the conserved SET domain, which is responsible for catalyzing methylation. Seven LoF variants occurred at the same two-base deletion at the exon 16 splice acceptor (c.4582-2delAG>-).