γ	d ∈{2,4,6,8,10,12,15,20} for LoF variants
γ	∈{1,2,4} for LoF inherited and case-control variants
γ	d ∈{1,2,4} for missense variants
γ	= 1 for missense inherited and case-control variants
k ∈{100,500,1000,2000}