Table 2.

Direction of changes and statistical significance of analyzed hydrophilic compounds of CSF fluid for MS vs control group

Compound		MS vs control	P value	VIP value	Published results
ppm	Assignment
8.46	Formate	↓	0.550
7.73	Hist	↓	0.261
7.39	Phe	↓	0.389
6.86	Tyr	↑	0.872
5.76	Urea	↓	0.006	1.57	↓ (Sinclair et al. 2010; Koneczny et al. 2014)
4.12	Lactate	↓	0.457
4.07	Myo-inositol	↓	0.015	1.13	↓ (Sinclair et al. 2010)
4.01	Betaine	↓	0.804
3.52	Gly	↓	0.782
3.36	1,3 dimethylurate	↓	0.358	1.45	↓ (Sinclair et al. 2010)
3.31	Cysteine	↓	0.274
3.25	Glucose	↓	0.693
3.21	Choline	↓	0.008	1.82	↓ (Sinclair et al. 2010)
3.16	Citrulline	↓	0.166
3.05	Creatinine	↓	0.007	1.19	↓ (Sinclair et al. 2010)
3.04	Creatine	↓	0.140
2.68	Citrate	↓	0.569
2.42	Gln	↓	0.872
2.38	Pyruvate	↓	0.550
2.28	Acetoacetate	↓	0.530
2.11	Methionine	↓	0.550
2.24	Acetone	↓	0.001	2.10	↓ (Sinclair et al. 2010)
2.13	Gln	↓	0.362
2.03	N-acetyl NH3 group	↓	0.942
1.93	Acetate	↓	0.942
1.72	Lys	↓	0.872
1.47	Ala	↓	0.849
1.34	Lactate	↓	0.511
1.21	3-OH-butyrate	↓	0.157	1.12	↓ (Sinclair et al. 2010)
1.03	Val	↓	0.257
0.96	Ile	↓	0.140	1.09	↓ (Sinclair et al. 2010)
0.9	Leu	↓	0.052	1.18	↓ (Sinclair et al. 2010)