Table 2.
Neuropathological observations
| Case no | Sport | Septum | CTE-NC | ADNC | CAA | TDP-43 | Other ND pathology | Clinical diagnosis | Integrated CPC diagnosis | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | C | |||||||||
| 1 | Soccer | F + C | High | 1 | 2 | 0 | 4 | – | CVD | AD | CTE |
| 2 | Soccer | C | High | 0 | 2 | 0 | 0 | 5 | CVD; PART | AD | VaD |
| 3 | Soccer | F | High | 2 | 3 | 3 | 2.25 | – | DLB | AD | DLB |
| 4 | Soccer | NA | High | 3 | 3 | 2 | 0 | 4 | CVD; ARTAG | Mixed AD/VaD | CTE |
| 5 | Soccer | C | Low | 3 | 3 | 2 | 3.5 | 3 | CVD; DLB; ARTAG | Mixed AD/VaD | AD |
| 6 | Soccer | Intact | No | 3 | 3 | 3 | 4 | – | ARTAG | ‘early onset dementia’ | AD |
| 7 | Soccer | Intact | No | 0 | 0 | 0 | 0 | 4 | PSP | AD | PSP |
| 8 | Rugby | F | High | 3 | 3 | 2 | 3 | 5 | ARTAG | VaD | CTE |
| 9 | Rugby | F | Low | 3 | 3 | 3 | 4 | 4 | CVD; ARTAG | AD | AD |
| 10 | Rugby | Intact | Low | 2 | 3 | 3 | 0.25 | 3 | CVD | AD | Mixed AD/VaD |
| 11 | Rugby | Intact | No | 0 | 0 | 0 | 0 | – | CBD | CTE | CBD |
AD Alzheimer’s disease, ADNC Alzheimer’s disease neuropathologic changes, ARTAG aging-related tau astrogliopathy, C cavum, CAA cerebral amyloid angiopathy [35]; CBD corticobasal degeneration,CPC clinicopathological correlation, CTE-NC chronic traumatic encephalopathy neuropathologic change, CVD chronic cerebrovascular disease, DLB dementia with Lewy bodies, F fenestrated, NA not assessed, ND neurodegenerative disease, PART primary age-related tauopathy, PSP progressive supranuclear palsy, TDP-43 abnormally phosphorylated TDP-43 pathology [16], VaD vascular dementia