FIG 7.

Proposed model for QseC and VisP role. Blocking of QseC phosphorylation by LED209 or knockout of qseC prevents the recognition of environmental signals and inhibits the transcription cascade of virulence genes in vivo. (A) Interruption of this pathway triggers other survival mechanisms, such as transcription of visP. (B) In vitro, the periplasmic protein VisP plays a role under different pH conditions between O104:H4 Stx⁺ and Stx^– strains, and TIF mediates attachment on the abiotic surface.