Table 2.
Regional brain monoamine concentrations
| PFC | ||
| Monoamine | WT | KO |
| NE | 317.6 (24.3) | 282.8 (23.8) |
| 5-HIAA | 1368.8 (95.9) | 1378.7 (97.5) |
| 5-HT | 1510 (22.5) | 1408.8 (22.6) |
| STR | ||
| WT | KO | |
| NE | 109.6 (14.0) | 114.9 (13.7) |
| DOPAC | 1404.2 (181.1) | 1503.5 (173.9) |
| DA | 4706.1 (625.4) | 4185.7 (614.1) |
| 5-HIAA | 1103.6 (78.4) | 989.2 (77.3) |
| HVA | 439.2 (51.1) | 526.9 (53.2) |
| 5-HT | 803.0 (76.3) | 688.5 (72.6) |
| NAcc | ||
| WT | KO | |
| NE | 1140.8 (168.6) | 1159.5 (157.7) |
| DOPAC | 951.1 (172.8) | 1038.0 (164.7) |
| DA | 2318.8 (412.8) | 2520.3 (412.4) |
| 5-HIAA | 1604.7 (82.0) | 1544.4 (75.8) |
| HVA | 262.7 (44.3) | 238.9 (38.6) |
| 5-HT | 1509.8 (160.4) | 1408.8 (157.4) |
| HIP | ||
| Monoamine | WT | KO |
| NE | 312.14 (21.9) | 353.7 (20.0) |
| 5-HIAA | 866.2 (38.4) | 886.1 (36.8) |
| 5-HT | 464.1 (71.7) | 441.3 (95.8) |
| Cb | ||
| WT | KO | |
| NE | 210.67 (9.7) | 180.02 (9.2) |
| DOPAC | 60.4 (6.2) | 51.3 (5.6) |
| 5-HIAA | 179.5 (10.5) | 157.9 (10.5) |
| 5-HT | 113.8 (12.9) | 116.0 (12.5) |
Values are Mean (SEM) (pg/mg tissue)
WT: n=16, KO: n=16.