Table 5.

Univariate (A) and multivariate (B) Cox regression analysis for OS of patients with rectal cancer.

Variables	Level	HR (95% CI)	p
Gender (ref = Male)	Female	0.81 (0.28–2.40)	0.709
Race (ref = White)	Others	1.77 (0.37–8.41)	0.476
PS ECOG (ref=0–1)	≥ 2	0.73 (0.16–3.30)	0.680
Histology Differentiation (ref = Well/Moderate)	Poorly differentiation	4.60 (1.20–17.59)	0.026
Liver metastasis (ref = No)	Yes	1.22 (0.39–3.85)	0.729
Peritoneum metastasis (ref = No)	Yes	0.69 (0.09–5.39)	0.722
Lung metastasis (ref = No)	Yes	0.99 (0.31–3.11)	0.981
Prior Operation (ref = No)	Yes	0.94 (0.33–2.69)	0.902
Max2, per 1SD (SD = 0.046) increase	Female	1.19 (0.80–1.77)	0.405
Age at Diagnosis, per 5 years old increase		1.02 (0.70–1.48)	0.932
CIRS-G severity index		1.25 (0.65–2.38)	0.505
Number of CIRS-G score 3 (ref=0)	1	2.23 (0.59–8.37)	0.236
	>=2	1.34 (0.35–5.10)	0.664
Number of CIRS-G score 4 (ref=0)	>=1	0.00 (0.00-.)	0.995
HEART (ref=0)	1–4	0.63 (0.08–4.99)	0.665
VASCULAR (ref=0)	1–4	0.32 (0.10–1.01)	0.051
HEMATOPOIETIC (ref=0)	1–4	NA	NA
RESPIRATORY (ref=0)	1–4	3.13 (1.10–8.88)	0.032
EENT_LARYNX (ref=0)	1–4	1.24 (0.45–3.47)	0.676
UPPER_GI (ref=0)	1–4	1.08 (0.34–3.44)	0.901
LOWER_GI (ref=0)	1–4	1.91 (0.60–6.06)	0.271
LIVER (ref=0)	1–4	NA	NA
RENAL (ref=0)	1–4	4.91 (1.34–17.91)	0.016
GENITOURINARY (ref=0)	1–4	0.93 (0.31–2.75)	0.893
MUSCULOSKELETAL (ref=0)	1–4	0.84 (0.30–2.36)	0.737
NEUROLOGICAL (ref=0)	1–4	1.39 (0.18–11.02)	0.756
ENDOCRINE (ref=0)	1–4	1.57 (0.46–5.34)	0.468
PSYCHIATRIC_ILLNESS (ref=0) Total Risk Score (ref 0–1)	1–4 >=2	1.35 (0.29–6.27) 4.32 (1.32–14.12)	0.704 0.015

(b)
Variables	Level	HR (95% CI)	p
Histology Differentiation (ref = Well/Moderate)	Poorly differentiation	14.63 (2.63, 81.56)	0.002
Total risk score	>=2	7.49 (1.81, 31.09)	0.006