Figure 1.

Tonic-clonic seizure transitions and spontaneous termination. A, Membrane potential of a single excitatory pyramidal neuron from the network B. A transient DC input (green line) resulted in a depolarization of the neurons and generation of seizure-like activity which continued past the stimulation offset. The resulting seizure-like discharge exhibited several state transitions between tonic (asynchronous firing) and clonic (bursting) periods before spontaneous termination. The bottom plots show activity during bursting (left) and tonic (right) periods. B, Heatmap showing membrane voltage of all pyramidal neurons in the network. Shows highly synchronized firing during bursting episodes. This figure is adapted from (Krishnan and Bazhenov, 2011).