Figure 2.

Cl⁻-dependent activation of KCC2 leads to gradual accumulation of [K⁺]_o and ictogenesis. A, Mean [Cl⁻]_i (left) and [K⁺]_o (right) for excitatory neurons in a “healthy” network, and a “pathological” reduced A-current network (red and black respectively). The blue trace indicates the pattern of synchronized interneuron stimulation. B and C, network-wide [Cl⁻]_i and [K⁺]_o for excitatory neurons. D, Overlay of the spiking of a single excitatory neuron (black) from the “pathological” network, and the corresponding [Cl⁻]_i (green), [K⁺]_o (purple), and interneuron stimulation (blue). This figure is adapted from (González et al., 2018).