Table 2:

Clinical and exposure measures between clusters

Cluster	1	2	3	4	p-value
Sample Size (n)	164	11	28	19
Age at Death (S.E.M)	84.7 (1.0)	72.5 (3.3)	82.4 (2.2)	84.7 (2.5)	<0.001*a,e
Gender m/f (%male)	89/73 (54.9%)	10/1 (83.3%)	19/9 (67.9%)	13/6 (68.4%)	0.062
Pathology Group (n)					<0.001
No CTE/No AD	65 (39.6%)	4 (36.4%)	6 (21.4%)	2 (10.5%)
AD	66 (40.2%)	0 (0%)	12 (42.9%)	12 (63.2%)	<0.05*a,e
CTE	24 (14.6%)	5 (45.5%)	2 (7.1%)	2 (10.5%)	<0.05*a,d
CTE & AD	9 (5.5%)	2 (18.2%)	8 (28.6%)	3 (15.8%)	<0.05*b
RHI y/n (%)	42/79 (34.7%)	10/0 (100%)	12/7 (63.2%)	8/4 (66.7%)	<0.001*a
Exposure years	5.4 (0.8)	16.7 (2.0)	7.6 (1.8)	7.9 (0.7)
LBD y/n (%)	52/112 (31.7%)	3/8 (27.3%)	12/16 (42.9%)	4/15 (21.1%)	0.443
CTE y/n (%)	33/131 (20.1%)	7/4 (63.6%)	10/18 (35.7%)	5/13 (26.3%)	<0.001*a
Stage I	1 (3%)	0 (0%)	1 (10%)	0 (0%)
Stage II	3 (9.1%)	2 (28.6%)	0 (0%)	0 (0%)
Stage III	16 (48.5%)	2 (28.6%)	2 (20%)	1 (20%)
Stage IV	13 (39.4%)	3 (42.9%)	7 (70%)	4 (80%)
Dementia	99/54 (64.7%)	8/3 (72.7%)	21/6 (77.8%)	16/3 (84.2%)	0.224

Participants with complete CAA data in all brain regions were used in hierarchical clustering analysis (n=222). Values are presented as mean (S.E.M.) years for age at death and contact sports exposure; mean yeas of exposure are for subjects with sports exposure >0; AD: Alzheimer disease; CTE: chronic traumatic encephalopathŷ LBD: Lewy body disease; RHI, repetitive head impacts;

^*χ² test for proportions,

^ap<0.05 for comparison between clusters 1 and 2,

^bp<0.05 for comparison between clusters 1 and 3,

^cp<0.05 for comparison between 1 and 4,

^dp<0.05 for comparison between clusters 2 and 3,

^ep<0.05 for comparison between clusters 2 and 4.