Table 2. Differential metabolites between CRT responders and non-responders.

HMDB ID	Compound name	P-value	VIP	Fold Change
Peripheral venous blood
HILIC/ESI+ mode
HMDB0003905	Imidazole-4-acetaldehyde	1.67E-02	1.728	1.48
HMDB0000214	Ornithine	1.81E-02	2.096	1.91
HMDB0000517	L-arginine	5.61E-03	2.072	1.37
HMDB0000670	Homo-L-arginine	3.03E-03	2.329	1.73
HMDB0005015	N6, N6, N6-Trimethyl-L-lysine	1.29E-02	1.729	1.55
HMDB0038662	N-(1-Deoxy-1-fructosyl) alanine	4.93E-02	1.312	1.56
HMDB0037842	N-(1-Deoxy-1-fructosyl) serine	2.01E-02	1.485	1.66
HMDB0028965	Lysyl-Gamma-glutamate	4.36E-03	1.904	2.53
HMDB0037840	N-(1-Deoxy-1-fructosyl) leucine	1.55E-02	1.609	1.63
HMDB0002089	N-Ribosylhistidine	2.48E-02	1.809	1.68
HMDB0037845	N-(1-Deoxy-1-fructosyl) tyrosine	8.78E-03	1.680	1.70
HILIC/ESI− mode
HMDB0000251	Taurine	2.28E-03	2.259	1.67
HMDB0000517	L-arginine	6.74E-04	2.256	1.88
HMDB0038662	N-(1-Deoxy-1-fructosyl) alanine	3.01E-02	1.451	1.69
HMDB0037840	N-(1-Deoxy-1-fructosyl) leucine	3.71E-02	1.403	1.63
HMDB0037846	N-(1-Deoxy-1-fructosyl) phenylalanine	1.15E-02	1.736	1.77
RPLC/ESI+ mode
HMDB0000517	L-arginine	1.50E-02	1.862	1.39
HMDB0062594	Methyl Arachidonate	4.89E-02	1.462	1.78
HMDB0010384	LysoPC (18:0)	8.88E-03	1.732	1.35
RPLC/ESI− mode
HMDB0004702	12,13-EpOME	4.87E-02	2.208	0.69
HMDB0007850	LPA (0:0/18:0)	1.93E-02	1.760	1.23
HMDB0062312	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate	2.35E-02	2.072	1.37
HMDB0011130	LysoPE (18:0/0:0)	2.21E-02	1.723	1.22
HMDB0010386	LysoPC (18:2(9Z,12Z))	4.84E-02	1.493	1.23
HMDB0007075	DG (15:0/18:3(6Z,9Z,12Z)/0:0)	3.56E-02	1.750	1.62
Coronary sinus blood
HILIC/ESI+ mode
HMDB0036803	Lysyl-Gamma-glutamate	3.29E-02	1.972	2.08
HILIC/ESI− mode
HMDB0028965	Stearic acid	2.48E-02	2.500	0.76
HMDB0000827	6-O-Acetylaustroinulin	5.89E-03	2.742	0.69
RPLC/ESI+ mode
HMDB0000517	L-arginine	4.72E-02	1.588	1.37
HMDB0030123	(3beta,5alpha,24S)-Ergost-8(14)-en-3-ol	1.22E-02	2.184	0.89
RPLC/ESI− mode
HMDB0000827	Stearic acid	3.59E-02	1.953	0.74

CRT: cardiac resynchronization therapy.