Table 4.

Univariate and multivariate Cox regression analyses for each clinical feature

Clinical feature	Univariate analysis			Multivariate analysis
HR	95% CI of HR	p-value	HR	95% CI of HR	p-value
Risk score (low-risk/high-risk)	2.019	1.412–2.886	0	2.381	1.355–4.184	0.003
Age (≤60/>60)	1.215	0.856–1.724	0.275
Sex (Female/Male)	0.815	0.572–1.161	0.257
Tumor size (T1/T2/T3/T4)	1.674	1.397–2.007	0	1.723	0.678–4.379	0.253
Metastatic diagnosis (yes/no)	3.977	1.250–12.652	0.019	0.854	0.180–4.061	0.843
Pathologic stage (I/II/III/IV)	1.661	1.355–2.036	0	1.129	0.406–3.315	0.816
Race (Asian/white/other)	1.141	0.948–1.375	0.164
Vascular invasion (macro/micro/none)	0.730	0.527–1.010	0.057
Fibrosis ishak score (1,2/3,4/5/6)	0.929	0.799–1.079	0.355
Child pugh grade (A/B/C)	1.523	0.836–2.775	0.170
New tumor events (yes/no)	0.540	0.343–0.849	0.008	0.548	0.276–1.087	0.085
Neoplasm cancer status (yes/no)	1.502	1.056–2.138	0.024	1.193	0.654–2.175	0.566

Abbreviations: HR, hazard ratio; CI, confidence interval.