Skip to main content
. 2019 Aug 6;12:6203–6216. doi: 10.2147/OTT.S213833

Table 2.

Univariate and multivariate Cox regression analyses of overall survival

Characteristic Training set Validation set Combined set
HR (95% CI) P-value HR (95% CI) P-value HR (95% CI) P-value
Univariate analyses
Gender 1.071 (0.476–2.413) 0.868 5.316 (0.732–38.629) 0.099 1.747 (0.844–3.619) 0.133
Age 0.761 (0.338–1.714) 0.761 0.582 (0.208–1.626) 0.302 0.650 (0.345–1.224) 0.182
Tumor number 1.379 (0.658–2.892) 0.395 2.291 (1.213–4.329) 0.011 1.835 (1.137–2.963) 0.013
Tumor diameter 1.943 (0.863–4.374) 0.109 3.529 (1.259–9.889) 0.016 2.582 (1.371–4.865) 0.003
AFP 1.197 (0.652–2.199) 0.562 2.176 (1.138–4.163) 0.019 1.650 (1.069–2.545) 0.024
PVTT 1.694 (0.749–3.832) 0.205 1.776 (0.876–3.601) 0.111 1.840 (1.081–3.134) 0.025
Microsatellite 4.082 (1.911–8.720) <0.001 2.357 (1.209–4.594) 0.012 3.201 (1.938–5.287) <0.001
MVI 1.349 (0.734–2.479) 0.334 2.519 (1.335–4.754) 0.004 1.831 (1.185–2.829) 0.006
TNM stage 2.011 (1.092–3.702) 0.025 2.340 (1.295–4.230) 0.005 2.197 (1.438–3.359) <0.001
ELMO1-AS1 expression 0.490 (0.262–0.914) 0.025 0.386 (0.206–0.724) 0.003 0.403 (0.258–0.629) <0.001
Multivariate analyses
Gender
Age
Tumor number 1.514 (0.687–3.336) 0.304 1.438 (0.822–2.514) 0.203
Tumor diameter 2.381 (0.808–7.022) 0.116 1.811 (0.932–3.520) 0.080
AFP 1.293 (0.626–2.669) 0.487 1.367 (0.868–2.152) 0.178
PVTT 1.075 (0.604–1.914) 0.805
Microsatellite 2.794 (1.311–5.954) 0.008 1.337 (0.663–2.912) 0.465 2.013 (1.159–3.496) 0.013
MVI 1.382 (0.663–2.880) 0.387 1.271 (0.782–2.064) 0.333
TNM stage 1.825 (0.987–3.374) 0.055 1.486 (0.764–2.891) 0.243 2.359 (0.828–2.233) 0.225
ELMO1-AS1 expression 0.518 (0.277–0.968) 0.039 0.430 (0.225–0.824) 0.011 0.407 (0.257–0.643) <0.001

Abbreviations: AFP, alpha-fetoprotein; PVTT, portal vein tumor thrombus; MVI, microvascular invasion.