Table 2.
Univariate and multivariate Cox regression analyses of overall survival
Characteristic | Training set | Validation set | Combined set | |||
---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
Univariate analyses | ||||||
Gender | 1.071 (0.476–2.413) | 0.868 | 5.316 (0.732–38.629) | 0.099 | 1.747 (0.844–3.619) | 0.133 |
Age | 0.761 (0.338–1.714) | 0.761 | 0.582 (0.208–1.626) | 0.302 | 0.650 (0.345–1.224) | 0.182 |
Tumor number | 1.379 (0.658–2.892) | 0.395 | 2.291 (1.213–4.329) | 0.011 | 1.835 (1.137–2.963) | 0.013 |
Tumor diameter | 1.943 (0.863–4.374) | 0.109 | 3.529 (1.259–9.889) | 0.016 | 2.582 (1.371–4.865) | 0.003 |
AFP | 1.197 (0.652–2.199) | 0.562 | 2.176 (1.138–4.163) | 0.019 | 1.650 (1.069–2.545) | 0.024 |
PVTT | 1.694 (0.749–3.832) | 0.205 | 1.776 (0.876–3.601) | 0.111 | 1.840 (1.081–3.134) | 0.025 |
Microsatellite | 4.082 (1.911–8.720) | <0.001 | 2.357 (1.209–4.594) | 0.012 | 3.201 (1.938–5.287) | <0.001 |
MVI | 1.349 (0.734–2.479) | 0.334 | 2.519 (1.335–4.754) | 0.004 | 1.831 (1.185–2.829) | 0.006 |
TNM stage | 2.011 (1.092–3.702) | 0.025 | 2.340 (1.295–4.230) | 0.005 | 2.197 (1.438–3.359) | <0.001 |
ELMO1-AS1 expression | 0.490 (0.262–0.914) | 0.025 | 0.386 (0.206–0.724) | 0.003 | 0.403 (0.258–0.629) | <0.001 |
Multivariate analyses | ||||||
Gender | ||||||
Age | ||||||
Tumor number | 1.514 (0.687–3.336) | 0.304 | 1.438 (0.822–2.514) | 0.203 | ||
Tumor diameter | 2.381 (0.808–7.022) | 0.116 | 1.811 (0.932–3.520) | 0.080 | ||
AFP | 1.293 (0.626–2.669) | 0.487 | 1.367 (0.868–2.152) | 0.178 | ||
PVTT | 1.075 (0.604–1.914) | 0.805 | ||||
Microsatellite | 2.794 (1.311–5.954) | 0.008 | 1.337 (0.663–2.912) | 0.465 | 2.013 (1.159–3.496) | 0.013 |
MVI | 1.382 (0.663–2.880) | 0.387 | 1.271 (0.782–2.064) | 0.333 | ||
TNM stage | 1.825 (0.987–3.374) | 0.055 | 1.486 (0.764–2.891) | 0.243 | 2.359 (0.828–2.233) | 0.225 |
ELMO1-AS1 expression | 0.518 (0.277–0.968) | 0.039 | 0.430 (0.225–0.824) | 0.011 | 0.407 (0.257–0.643) | <0.001 |
Abbreviations: AFP, alpha-fetoprotein; PVTT, portal vein tumor thrombus; MVI, microvascular invasion.