Table 3.

Univariate and multivariate Cox regression analyses of disease-free survival

Characteristic	Training set		Validation set		Combined set
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Univariate analyses
Gender	1.110 (0.543–2.267)	0.775	8.868 (1.228–64.043)	0.030	1.982 (1.036–3.792)	0.039
Age	1.031 (0.544–1.953)	0.925	0.830 (0.394–1.746)	0.624	0.921 (0.569–1.490)	0.736
Tumor number	1.501 (0.774–2.910)	0.229	1.836 (1.058–3.185)	0.031	1.713 (1.124–2.609)	0.012
Tumor diameter	1.745 (0.901–3.378)	0.099	1.637 (0.830–3.230)	0.155	1.732 (1.079–2.782)	0.023
AFP	1.127 (0.667–1.905)	0.655	1.798 (1.064–3.037)	0.028	1.461 (1.013–2.106)	0.042
PVTT	2.162 (1.052–4.443)	0.036	1.656 (0.894–3.065)	0.109	1.905 (1.194–3.039)	0.007
Microsatellite	1.351 (0.578–3.162)	0.488	2.030 (1.143–3.604)	0.016	1.886 (1.182–3.009)	0.008
MVI	1.709 (1.005–2.906)	0.048	1.872 (1.119–3.133)	0.017	1.773 (1.226–2.565)	0.002
TNM stage	1.296 (0.744–2.259)	0.360	1.933 (1.160–3.220)	0.011	1.1623 (1.117–2.356)	0.011
ELMO1-AS1 expression	0.546 (0.320–0.930)	0.026	0.556 (0.334–0.926)	0.024	0.469 (0.323–0.681)	<0.001
Multivariate analyses
Gender			7.808 (1.066–57.205)	0.043	1.762 (0.916–3.389)	0.090
Age
Tumor number			1.195 (0.609–2.346)	0.605	1.605 (0.968–2.661)	0.067
Tumor diameter					1.462 (0.884–2.416)	0.139
AFP			1.448 (0.798–2.627)	0.224	1.237 (0.835–1.832)	0.290
PVTT	1.574 (0.741–3.345)	0.238			1.246 (0.745–2.084)	0.403
Microsatellite			1.369 (0.703–2.665)	0.356	1.067 (0.623–1.827)	0.812
MVI	1.642 (0.947–2.849)	0.077	1.072 (0.574–2.002)	0.826	1.466 (0.973–2.210)	0.067
TNM stage			1.535 (0.863–2.730)	0.145	0.999 (0.642–1.556)	0.998
ELMO1-AS1 expression	0.557 (0.323–0.960)	0.035	0.616 (0.363–1.045)	0.072	0.476 (0.324–0.699)	<0.001

Abbreviations: AFP, alpha-fetoprotein; PVTT, portal vein tumor thrombus; MVI, microvascular invasion.