Table 1.
GO analysis of genes in turquoise module
| ONTOLOGY | ID | Description | p-value | p. adjust | q-value | Count |
|---|---|---|---|---|---|---|
| BP | GO:0042110 | T cell activation | 5.75E-26 | 2.92E-22 | 2.52E-22 | 89 |
| BP | GO:0007159 | Leukocyte cell-cell adhesion | 2.06E-21 | 5.23E-18 | 4.52E-18 | 68 |
| BP | GO:0050867 | Positive regulation of cell activation | 4.76E-20 | 8.07E-17 | 6.97E-17 | 69 |
| BP | GO:0050870 | Positive regulation of T cell activation | 1.33E-19 | 1.44E-16 | 1.25E-16 | 51 |
| BP | GO:0051249 | Regulation of lymphocyte activation | 1.42E-19 | 1.44E-16 | 1.25E-16 | 78 |
| BP | GO:1903039 | Positive regulation of leukocyte cell-cell adhesion | 2.53E-19 | 2.15E-16 | 1.85E-16 | 52 |
| BP | GO:0050863 | Regulation of T cell activation | 3.91E-19 | 2.84E-16 | 2.46E-16 | 63 |
| BP | GO:0002696 | Positive regulation of leukocyte activation | 5.76E-19 | 3.66E-16 | 3.16E-16 | 66 |
| BP | GO:0070661 | Leukocyte proliferation | 2.41E-18 | 1.36E-15 | 1.17E-15 | 57 |
| BP | GO:0022409 | Positive regulation of cell-cell adhesion | 6.12E-18 | 3.11E-15 | 2.69E-15 | 54 |
| BP | GO:1903037 | Regulation of leukocyte cell-cell adhesion | 6.81E-18 | 3.15E-15 | 2.72E-15 | 59 |
| BP | GO:0022407 | Regulation of cell-cell adhesion | 8.12E-18 | 3.44E-15 | 2.97E-15 | 68 |
| BP | GO:0046651 | Lymphocyte proliferation | 4.99E-17 | 1.95E-14 | 1.69E-14 | 53 |
| BP | GO:0032943 | MONONUCLEAR cell proliferation | 7.07E-17 | 2.57E-14 | 2.22E-14 | 53 |
| BP | GO:0045785 | Positive regulation of cell adhesion | 2.04E-16 | 6.91E-14 | 5.97E-14 | 66 |
| BP | GO:0051251 | Positive regulation of lymphocyte activation | 2.26E-16 | 7.19E-14 | 6.21E-14 | 58 |
| BP | GO:0002521 | Leukocyte differentiation | 5.83E-16 | 1.74E-13 | 1.50E-13 | 74 |
| BP | GO:0030098 | Lymphocyte differentiation | 2.00E-15 | 5.66E-13 | 4.89E-13 | 58 |
| BP | GO:0002768 | Immune response-regulating cell surface receptor signaling pathway | 5.64E-15 | 1.51E-12 | 1.30E-12 | 72 |
| BP | GO:0050851 | Antigen receptor-mediated signaling pathway | 7.82E-15 | 1.99E-12 | 1.72E-12 | 52 |
| BP | GO:0042113 | B cell activation | 3.43E-14 | 8.29E-12 | 7.16E-12 | 50 |
| BP | GO:0002429 | Immune response-activating cell surface receptor signaling pathway | 1.93E-13 | 4.46E-11 | 3.85E-11 | 66 |
| BP | GO:0050670 | Regulation of lymphocyte proliferation | 8.15E-13 | 1.80E-10 | 1.56E-10 | 40 |
| BP | GO:0032944 | Regulation of mononuclear cell proliferation | 9.64E-13 | 1.96E-10 | 1.70E-10 | 40 |
| BP | GO:0001819 | Positive regulation of cytokine production | 9.66E-13 | 1.96E-10 | 1.70E-10 | 61 |
| CC | GO:0042613 | MHC class II protein complex | 1.51E-14 | 8.70E-12 | 7.81E-12 | 13 |
| CC | GO:0042611 | MHC protein complex | 8.87E-11 | 2.56E-08 | 2.30E-08 | 13 |
| CC | GO:0045121 | Membrane raft | 5.23E-08 | 8.29E-06 | 7.44E-06 | 41 |
| CC | GO:0098857 | Membrane microdomain | 5.74E-08 | 8.29E-06 | 7.44E-06 | 41 |
| CC | GO:0098589 | Membrane region | 1.55E-07 | 1.79E-05 | 1.60E-05 | 41 |
| CC | GO:0042101 | T cell receptor complex | 2.15E-07 | 2.07E-05 | 1.86E-05 | 9 |
| CC | GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | 3.81E-07 | 3.14E-05 | 2.82E-05 | 21 |
| CC | GO:0009898 | Cytoplasmic side of plasma membrane | 9.07E-07 | 6.54E-05 | 5.87E-05 | 27 |
| CC | GO:0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | 1.59E-06 | 9.20E-05 | 8.26E-05 | 10 |
| CC | GO:0098553 | Lumenal side of endoplasmic reticulum membrane | 1.59E-06 | 9.20E-05 | 8.26E-05 | 10 |
| CC | GO:0030669 | Clathrin-coated endocytic vesicle membrane | 1.89E-06 | 9.90E-05 | 8.89E-05 | 12 |
| CC | GO:0030665 | Clathrin-coated vesicle membrane | 2.70E-06 | 0.00013 | 0.000117 | 19 |
| CC | GO:0098562 | Cytoplasmic side of membrane | 9.80E-06 | 0.000435 | 0.00039 | 27 |
| CC | GO:0009897 | External side of plasma membrane | 1.49E-05 | 0.000616 | 0.000552 | 34 |
| CC | GO:0019897 | Extrinsic component of plasma membrane | 1.70E-05 | 0.000655 | 0.000588 | 24 |
| CC | GO:0015629 | Actin cytoskeleton | 2.15E-05 | 0.000743 | 0.000667 | 49 |
| CC | GO:0045334 | Clathrin-coated endocytic vesicle | 2.19E-05 | 0.000743 | 0.000667 | 13 |
| CC | GO:0031252 | Cell leading edge | 2.75E-05 | 0.000881 | 0.000791 | 41 |
| CC | GO:0030136 | Clathrin-coated vesicle | 3.66E-05 | 0.00111 | 0.000996 | 24 |
| CC | GO:0001772 | Immunological synapse | 4.53E-05 | 0.001306 | 0.001172 | 9 |
| CC | GO:0030139 | Endocytic vesicle | 0.000105 | 0.002875 | 0.00258 | 32 |
| CC | GO:0042629 | Mast cell granule | 0.00011 | 0.00289 | 0.002594 | 7 |
| CC | GO:0030662 | Coated vesicle membrane | 0.000141 | 0.003459 | 0.003104 | 22 |
| CC | GO:0043235 | Receptor complex | 0.000144 | 0.003459 | 0.003104 | 38 |
| CC | GO:0030666 | Endocytic vesicle membrane | 0.000163 | 0.003759 | 0.003374 | 21 |
| CC | GO:0005925 | Focal adhesion | 0.000193 | 0.004292 | 0.003852 | 39 |
| MF | GO:0032395 | MHC class II receptor activity | 3.00E-09 | 2.80E-06 | 2.64E-06 | 8 |
| MF | GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | 2.28E-06 | 0.001066 | 0.001002 | 13 |
Abbreviations: BP, biological process; CC, cellular component; GO, Gene Ontology; MF, molecular function.