Table 1.
Characteristics of the participants in total and in three age groups
| Age | 19–39, N = 147 M:29 (SD:5) | 40–59, N = 123 M:51 (SD:5) | 60–80, N = 292 M:67 (SD:5) | Total, N = 562 M:54 (SD:5) |
|---|---|---|---|---|
| Sex, women, N (%) | 98 (66.7) | 57 (46.3) | 164 (56.2) | 319 (56.8) |
| Education (years), mean (SD) | 15.9 (2.3) | 16 (2.3) | 16.3 (2.4) | 16 (2.4) |
| Speed, mean (SD) | 0.72 (0.7) | 0.056 (0.8) | −0.36 (0.8) | 0.0003 (0.9) |
| Executive, mean (SD) | 0.20 (0.6) | −0.012 (0.7) | −0.11 (0.6) | −0.011 (0.6) |
| Episodic memory, mean (SD) | 0.62 (0.7) | 0.13 (0.9) | −0.34 (1) | 0.0 (1) |
| General cognition, mean (SD) | 1.5 (1.4) | 0.7 (1.7) | −0.8 (1.7) | −0.01 (1.9) |
| Cortical thickness (mm), mean (SD) | 2.63 (0.1) | 2.56 (0.1) | 2.48 (0.1) | 2.54 (0.1) |
| Entorhinal thickness (mm), mean (SD) | 3.36 (0.4) | 3.42 (0.4) | 3.3 (0.4) | 3.34 (0.4) |
| Parahippocampal thickness (mm), mean (SD) | 2.81 (0.3) | 2.75 (0.3) | 2.7 (0.3) | 2.7 (0.3) |
| Hippocampal volume (mm3), mean (SD) | 4,220.3 (419.7) | 4,198.4 (448.8) | 3,804.2 (464.7) | 4,013 (491.8) |
| Striatum volume (mm3), mean (SD) | 4,614.8 (474.9) | 4,279.7 (529.2) | 3,878.2 (562.5) | 4,179.9 (617.8) |
| DN, mean (SD) | 0.090 (0.05) | 0.070 (0.03) | 0.064 (0.03) | 0.073 (0.04) |
| FPCN, mean (SD) | 0.075 (0.05) | 0.063 (0.04) | 0.06 (0.04) | 0.065 (0.04) |
| FA, mean (SD) | 0.453 (0.02) | 0.448 (0.02) | 0.438 (0.02) | 0.444 (0.02) |
| WMH burden, mean (SD) | 0.71 (0.9) | 1.62 (1) | 2.67 (1) | 1.91 (1.3) |
Abbreviations: DN, default‐mode network; FA, fractional anisotropy; FPCN, fronto‐parietal control network; WMH, white matter hyperintensity.