Table 2.
Genotype frequency of LEP, LEPR, DRD2, HTR2A, and HTR2C polymorphisms among patients with and without impaired fasting glucose
| Risperidone | Clozapine | |||||||
|---|---|---|---|---|---|---|---|---|
| NFGa (n=90) | IFGb (n=40) | p-valuec | OR (95% CI)d | NFGa (n=18) | IFGb (n=32) | p-valuec | OR (95% CI)d | |
| LEP rs7799039 (G>A) | ||||||||
| GG | 9 (100.0) | 0 (0.0) | 0.008 | 3.28 (1.44–7.50) | 2 (40.0) | 3 (60.0) | 0.913 | 0.78 (0.24–2.48) |
| AG | 38 (79.2) | 10 (20.8) | 7 (31.8) | 15 (68.2) | ||||
| AA | 43 (58.9) | 30 (41.1) | 9 (39.1) | 14 (60.9) | ||||
| LEPR rs1137101 (A>G) | ||||||||
| AA | 4 (100.0) | 0 (0.0) | 0.427 | 1.92 (0.84–4.36) | 0 (0.0) | 1 (100.0) | >0.999 | 0.73 (0.19–2.82) |
| AG | 25 (71.4) | 10 (28.6) | 4 (33.3) | 8 (66.7) | ||||
| GG | 61 (67.0) | 30 (33.0) | 14 (37.8) | 23 (62.2) | ||||
| DRD2 rs4436578 (T>C) | ||||||||
| TT | 45 (72.6) | 17 (27.4) | 0.116 | 1.35 (0.64–2.87) | 8 (44.4) | 10 (55.6) | 0.220 | 1.76 (0.53–5.80) |
| CT | 37 (72.5) | 14 (27.5) | 7 (25.9) | 20 (74.1) | ||||
| CC | 8 (47.1) | 9 (52.9) | 3 (60.0) | 2 (40.0) | ||||
| HTR2A rs6313 (T>C) | ||||||||
| TT | 36 (67.9) | 17 (32.1) | 0.964 | 0.90 (0.42–1.92) | 9 (37.5) | 15 (62.5) | >0.999 | 1.13 (0.36–3.60) |
| CT | 43 (69.4) | 19 (30.6) | 7 (33.3) | 14 (66.7) | ||||
| CC | 11 (73.3) | 4 (26.7) | 2 (40.0) | 3 (60.0) | ||||
| HTR2C rs518147 (G>C) | ||||||||
| GG | 70 (70.0) | 30 (30.0) | 0.269 | 1.17 (0.49–2.79) | 13 (39.4) | 20 (60.6) | 0.565 | 1.56 (0.45–5.47) |
| CG | 14 (77.8) | 4 (22.2) | 4 (40.0) | 6 (60.0) | ||||
| CC | 6 (50.0) | 6 (50.0) | 1 (14.3) | 6 (85.7) | ||||
| HTR2C rs12836771 (A>G) | ||||||||
| AA | 73 (70.9) | 30 (29.1) | 0.332 | 1.43 (0.59–3.48) | 14 (37.8) | 23 (62.2) | 0.889 | 1.37 (0.35–5.30) |
| AG | 11 (73.3) | 4 (26.7) | 3 (37.5) | 5 (62.5) | ||||
| GG | 6 (50.0) | 6 (50.0) | 1 (20.0) | 4 (80.0) | ||||
Notes: aNFG: normal fasting plasma glucose. bIFG: increased fasting plasma glucose. cχ2 test (Pearson chi-square or Fisher’s exact) for the genotype frequencies between NFG and IFG groups dOdds ratio (95% confidence interval): Recessive genetic model; LEP rs7799039: AA vs AG + GG; LEPR rs1137101: GG vs AG + GG. Dominant genetic model; DRD2 rs4436578: CC + CT vs TT; HTR2A rs6313: CC + CT vs TT; HTR2C rs518147: CC + CG vs.GG; HTR2C rs12836771: GG + AG vs AA.