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Schematic of Nav1.6. Na+ channels are comprised of a single polypeptide that is composed of four repeated domains (domains (D) I–IV), with each domain formed by six transmembrane segments (S1–S6); S1–S4 represent the voltage‐sensing region, while S5‐S6 forms the conducting pore. Shown is a schematic of the Nav1.6 protein, with DI‐IV and S1–S6 as well as the Nav1.6 variants included in this study (circles).
