Table 3.

Biophysical properties of wild‐type and Nav1.6 mutant channels.

Variant	PeakI Na density		Voltage dependence of activation			Persistent current		Decay	n
	pA/pF	n	V 1/2	k	n	% of peak	n	τ (ms)
Wild‐type	360.4 ± 16.6	28	−27.5 ± 0.7	5.2 ± 0.1	28	1.7 ± 0.2	31	0.8 ± 0.03	31
G1475R	371.8 ± 28.3	25	−28.1 ± 1.2	4.9 ± 0.3	25	7.2 ± 0.7***	28	1.1 ± 0.06	28
A1491V	397.6 ± 24.9	26	−33.6 ± 0.9***	4.2 ± 0.3	26	7.4 ± 0.8***	26	2.4 ± 0.15***	26
L483F	425.6 ± 24.6	22	−28.3 ± 0.8	4.8 ± 0.2	21	1.6 ± 0.2	23	0.8 ± 0.05	23
R1872L	434.1 ± 34.9	27	−32.9 ± 1.0***	4.7 ± 0.2	27	2.9 ± 0.4*	25	1.3 ± 0.11**	25
R1872W	461.8 ± 23.3	25	−29.7 ± 0.9	5.1 ± 0.2	25	5.8 ± 0.6***	25	1.7 ± 0.12***	25
V1758A	427.9 ± 28.1	23	−23.4 ± 1.1†	5.1 ± 0.2	23	1.1 ± 0.2	23	0.8 ± 0.07	23
N374K	447.9 ± 23.7	25	−33.2 ± 0.7***	4.9 ± 0.3	25	3.5 ± 0.3***	25	0.9 ± 0.06	25
M139I	385.2 ± 27.1	25	−34.4 ± 0.7***	5.9 ± 0.2	25	4.9 ± 0.5***	26	1.2 ± 0.12*	26

^† P = 0.052; *P < 0.05; **P < 0.01; ***P < 0.001; vs. wild‐type via one‐way ANOVA (with Bonferroni correction for multiple comparisons).

*P < 0.05; **P < 0.01; ***P < 0.001 vs. wild‐type (noncorrected).