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. 2019 Jul 9;6(8):1423–1434. doi: 10.1002/acn3.50837

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© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Comparison of translocator protein (TSPO) densities in the normal aged post mortem human brain measured by [³H]PK11195 and [³H]PBR28. Quantitative analysis of 2 nmol/L [³H]PK11195 and 2 nmol/L [³H]PBR28 binding in multiple brain regions of aged human healthy control cases (n = 8, aged 77–92 years). Non‐specific binding was determined by the presence of 1 µmol/L unlabeled PBR28 for [³H]PK11195 and 1 µmol/L PK11195 for [³H]PBR28. Specific receptor binding densities (fmol/mg) were calculated by subtracting nonspecific binding from total binding. Data was calculated from the average of 2–4 adjacent sections of each case and presented as mean ± SEM. Th, Thalamus; SN, Substantia nigra; Fr, Frontal cortex; Cd, Caudate; Pu, Putamen; RN, Red nucleus.