Table 3.

Clinical values derived from plasma from the WT and KO male and female rats

	Male		Female
	WT	KO	WT	KO
Glucose, mmol/l	10.00 ± 0.42	9.64 ± 0.63	8.89 ± 0.24*	9.45 ± 0.19
BUN, mmol/l	6.01 ± 0.56	5.47 ± 0.41	5.21 ± 0.43	6.19 ± 0.24
Creatinine, µmol/l	14.73 ± 1.86	17.68 ± 0.0L	17.68 ± 0.0	17.68 ± 0.0L
Phosphate, mmol/l	1.83 ± 0.07	1.90 ± 0.07L	1.54 ± 0.08‡	1.55 ± 0.08†L
Calcium, mmol /l	2.38 ± 0.02	2.38 ± 0.01	2.38 ± 0.04	2.38 ± 0.03
Albumin, g/l	25.80 ± 0.40	25.60 ± 0.50L	28.20 ± 1.3	28.10 ± 1.4L
Globulin, g/l	31.16 ± 0.54	32.66 ± 0.50	31.80 ± 0.40	32.30 ± 0.40
ALT, U/l	51.16 ± 5.41	50.83 ± 3.70H	41.0 ± 4.32	84.33 ± 26.68H
ALKP, U/l	279.8 ± 45.35	201.3 ± 42.92*	160.4 ± 30.09	155.16 ± 25.96
GGT, U/l	0.60 ± 0.33	0.17 ± 0.166	0.0 ± 0.0	1.33 ± 0.33*†
T. Bilirubin, µmol/l	2.28 ± 0.57	1.99+00.28	2.39 ± 0.42	3.13 ± 0.68
Cholesterol, mmol/l	1.73 ± 0.22	1.48 ± 0.18*	1.84 ± 0.16	1.63 ± 0.19
Triglycerides, mmol/l	0.83 ± 0.22	0.48 ± 0.08*L	0.77 ± 0.09	0.64 ± 0.12
Sodium, mmol/l	139.6 ± 0.42	142.5 ± 1.17	141.8 ± 0.58	140.6 ± 0.91
Potassium, mmol/l	4.33 ± 0.15	4.00 ± 0.11L	3.74 ± 0.08†	3.78 ± 0.10‡L
Chloride, mmol/l	101.83 ± 0.31	103.0 ± 0.97	101.6 ± 0.67	102.16 ± 0.75
Osm Calc, mmol/kg	284.6 ± 0.33	287.3 ± 2.75	284.8 ± 1.02	284.0 ± 1.98

Values are averages ± SE for n = 5–6. BUN, blood urea nitrogen; ALT, alanine aminotransferase; ALKP, alkaline phosphatase; GGT = gamma glutamyl transferase; H or L, outside the range reported for 13–22 wk old Charles River rats (https://www.criver.com/files/pdfs/rms/cd/rm_rm_r_clinical_parameters_cd_rat_06.aspx).

^*Significant differences between genotype but same sex;

^†significant differences between different sex of same genotype;

^‡significant difference between different sex and different genotype. Determined by ANOVA with Tukey’s post hoc.