Fig. 2.
Hepatocyte myeloid differentiation primary response gene 88 (Myd88) deletion (Myd88ΔHep) profoundly impacts bile acid metabolism. A: liver mRNA expression of bile acid synthesis enzymes measured by real-time qPCR in wild-type (WT) and Myd88ΔHep mice fed with either control diet (CT) or high-fat diet (HFD). B: cecal bile acid content. C: plasma (portal vein) bile acid content. Data are presented as means ± SE (n = 6–9 mice). CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; MCA, muricholic acid; T, taurine; UDCA, ursodeoxycholic acid; a, α, b, β, o, ω conjugated species. Significantly different according to 2-way ANOVA followed by Tukey post hoc test: *P < 0.05, **P < 0.01, ***P < 0.001.