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. 2019 Apr 24;317(1):C82–C92. doi: 10.1152/ajpcell.00418.2018

Fig. 4.

Fig. 4.

Cancer-cell derived microvesicles (MVs) alter fibroblast function independently of other secreted factors. A: cell area of fibroblasts treated with conditioned media (CM) or conditioned media supplemented with MVs (CM + MV) for 24 h on 20 kPa polyacrylamide (PA) gels (CM: n = 72, CM + MV: n = 78). B: traction force measurements of fibroblasts in CM and CM + MV culture conditions on 20 kPa PA gels (CM: n = 41, CM + MV: n = 50). C: traction stress measurements (Traction Force/Cell Area) of fibroblasts in CM and CM + MV culture conditions on 20 kPa PA gels (CM: n = 41, CM + MV: n = 50). D: representative traction stress maps of fibroblasts in CM and CM + MV culture conditions on 20 kPa PA gels. N = 3 independent sets of PA gels and MV isolations. Plots are median ± the minimum and maximum values. ****P < 0.0001 from Student’s unpaired t-test.