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. 2019 Apr 17;317(1):C58–C67. doi: 10.1152/ajpcell.00160.2017

Fig. 3.

Fig. 3.

Pyruvate dehydrogenase 1 (PDH1) is inhibited in Leigh syndrome French Canadian type (LSFC) fibroblasts. Immunoblot and densitometric analysis of total and/or phosphorylated levels of hypoxia-inducible factor 1α (HIF-1α, n = 5) and pyruvate dehydrogenase kinase 1 (PDHK1, n = 5; A) and PDH1-α (n = 8; B) in primary fibroblasts from control and LSFC donors. Results represent means ± SE. Difference between control and LSFC cells was assessed with a paired Student’s t-test. *P ≤ 0.05.