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. 2019 Aug 7;14:6231–6247. doi: 10.2147/IJN.S215447

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© 2019 Ibrahim et al.

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NMFTC antiretroviral activity. (A) HIV-1 RT activity in FTC and NMFTC pre-exposed MDMs showing complete inhibition with NMFTC for up to 10 days as compared with FTC that did not have effect beyond day 1 (mean±SD, n=9; ***P≤0.001). (B) HIV-1 p24 antigen staining showing results similar to RT assay demonstrated by the absence of p24 staining (brown color) for up to 10 days after NMFTC pre-exposure whereas FTC had no effect by day 1.

Abbreviations: RT, reverse transcriptase; FTC, emtricitabine; NMFTC, nanoparticle of modified FTC prodrug; MDM, monocyte-derived macrophage.