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MFTC enzymatic cleavage kinetics in plasmas of six different species demonstrate species difference in (A) prodrug hydrolysis; rate of hydrolysis: mouse, rat>rabbit>monkey>dog and human. (B) The hydrolyzed prodrug reverted back to the parent drug as indicated by increased formation of FTC.
Abbreviations: FTC, emtricitabine; MFTC, modified FTC prodrug.
