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NMFTC pharmacokinetics. Sprague-Dawley rats were injected IM with 45, 75 or 100 mg/kg FTC or FTC-equivalent dose of NMFTC. NMFTC resulted in significantly higher FTC concentrations, as compared to FTC, in rat (A) plasma, (B) liver, (C) spleen, (D) LNs and (E) brain. Results are shown as mean±SEM, n=3–5; *P≤0.05, **P≤0.01, ***P≤0.001.
Abbreviations: FTC, emtricitabine; NMFTC, nanoparticle of modified FTC prodrug; LN, lymph node; SEM, standard error of the mean.
