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. 2019 Aug 6;14:6269–6285. doi: 10.2147/IJN.S208938

Figure 4.

Figure 4

Treatment efficacy in mice bearing HeLa tumors. (A) The effect of the different treatments on HeLa tumors in mice was studied for 30 days. PTX containing P1 NPs, P2 NPs or nab-PTX were injected with 60 mg/kg PTX. Free PTX was injected twice (day 1 and 7); 15 mg/kg in each injection. The blue arrows indicate PTX injections. PBS was used as a control. Data are shown as mean±SEM (P1NPs: n=11; P2 NPs, nab-PTX and PTX: n=10). Statistical significance between the treatment groups was calculated using AUC of individual tumors. Error bars show SEM. Asterisks indicate statistical significance obtained by two-tailed unpaired t-test. *P<0.05, **P<0.005. (B) Relative tumor volume at day 18 after the treatment plotted before two treatment groups were discontinued due to very large tumors. Statistical significance was determined using two-tailed unpaired t-test. Error bars show SEM. Asterisks indicate level of significance of each data set (n=12 [PBS], n=11 [P1], n=10 [P2, nab-PTX, PTX]). *P<0.05, **P<0.005, ****P<0.0001.