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. 2019 May 15;122(1):358–367. doi: 10.1152/jn.00173.2019

Fig. 5.

Fig. 5.

A: means ± SE of 24-h mean arterial blood pressure (ABP) before and after unilateral clipping of the left renal artery of mice receiving ipsilateral renal denervation or selective afferent renal denervation. Control mice are replotted from Fig. 1. *P < 0.05, sham vs. ipsilateral (2K1C-ipsi) renal denervation; #P < 0.05, control vs. capsaicin (2K1C-CAP; 2-way ANOVA followed by t-test with layered Bonferroni correction). B: means ± SE and individual data points of changes (Δ) in mean ABP in response to the ganglionic blocker hexamethonium (30 mg/kg ip). *P < 0.05 vs. day 0 (paired t-test). Ganglionic blockade with hexamethonium did not produce a greater depressor response between days 0, 14, or 21 of ipsilateral renal denervation (P = 0.0967 from overall 1-way ANOVA) or capsaicin-treated groups (P = 0.06488 from overall 1-way ANOVA). Confirmation of the denervation using immunofluorescence is presented in Fig. 6.