Table 1.
Study characteristics
| Study | Study design | Number of patients | Age (years) | M:F | Study duration (months) | Kellgren and Lawrence grade |
|---|---|---|---|---|---|---|
| Deie et al (2007)14 | Case series | 6 | 51.7±8.5 | 2:4 | 21 | Grade 3 (17%), Grade 4 (83%) |
| Intema et al (2011)a,15 | Prospective study | 20 | 48.0±7.0 | 11:9 | 12 | Grade 1 (15%), Grade 2 (20%), Grade 3 (55%), Grade 4 (10%) |
| Wiegant et al (2013)a,16 | Prospective study | 20 | 48.0±7.0 | 11:9 | 24 | Grade 1 (15%), Grade 2 (20%), Grade 3 (55%), Grade 4 (10%) |
| van der Woude et al (2016)17 | Prospective study | 40 | 6-weeks: 48.6±3.0 8-weeks: 54.6±1.7 |
6-weeks: 1:1 8-weeks: 11:9 |
12 | 6-weeks: Grade 1 (10%), Grade 2 (15%), Grade 3 (45%), Grade 4 (30%) 8-weeks: Grade 1 (15%), Grade 2 (20%), Grade 3 (55%), Grade 4 (10%) |
| van der Woude et al (2016)b,24 | Randomized controlled trial | 67 | Knee joint distraction: 51.2±1.1 High tibial osteotomy: 49.4±1.0 |
Knee joint distraction: 8:3 High tibial osteotomy: 27:18 |
12 | Knee joint distraction: Grade 1 (27%), Grade 2 (18%), Grade 3 (50%), Grade 4 (5%) High tibial osteotomy: Grade 0 (2%), Grade 1 (11%), Grade 2 (27%), Grade 3 (51%), Grade 4 (9%) |
| van der Woude et al (2017)a,18 | Prospective study | 20 | 48.0±7.0 | 11:9 | 60 | Grade 1 (15%), Grade 2 (20%), Grade 3 (55%), Grade 4 (10%) |
| van der Woude et al (2017)b,25 | Randomized controlled trial | 56 | Knee joint distraction: 54.9±1.8 Total knee arthroplasty: 55.2±1.0 |
Knee joint distraction: 11:9 Total knee arthroplasty: 13:23 |
12 | Knee joint distraction: Grade 2 (5%), Grade 3 (40%), Grade 4 (55%) Total knee arthroplasty: Grade 2 (25%), Grade 3 (58%), Grade 4 (17%) |
| Jansen et al (2018)a,19 | Prospective study | 20 | 48.0±7.0 | 11:9 | 108 | Grade 1 (15%), Grade 2 (20%), Grade 3 (55%), Grade 4 (10%) |
| Jansen et al (2019)b,26 | Randomized controlled trial | 61 | Knee joint distraction: 51.2±1.1 High tibial osteotomy: 49.4±1.0 |
Knee joint distraction: 8:3 High tibial osteotomy: 27:18 |
24 | Knee joint distraction: Grade 1 (27%), Grade 2 (18%), Grade 3 (50%), Grade 4 (5%) High tibial osteotomy: Grade 0 (2%), Grade 1 (11%), Grade 2 (27%), Grade 3 (51%), Grade 4 (9%) |
| 53 | Knee joint distraction: 54.9±1.8 Total knee arthroplasty: 55.2±1.0 |
Knee joint distraction: 11:9 Total knee arthroplasty: 13:23 |
24 | Knee joint distraction: Grade 2 (5%), Grade 3 (40%), Grade 4 (55%) Total knee arthroplasty: Grade 2 (25%), Grade 3 (58%), Grade 4 (17%) |
Notes: aPublication of the same study at 12, 24, 60, and 108 months; bPublication of the same study at 12 and 24 months.