Table 3.
Univariate and multivariate survival analysis
| Variables |
Univariate analysis |
Multivariate analysis |
||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Age in yr, ≥ 60 vs < 60 | 0.806 | 0.481-1.352 | 0.414 | - - - | - - - | - - - |
| Gender, male vs female | 1.265 | 0.757-2.178 | 0.396 | - - - | - - - | - - - |
| Tumor site, colon vs rectum | 0.681 | 0.405-1.143 | 0.146 | - - - | - - - | - - - |
| Tumor size in cm, ≥ 5 vs < 5 | 0.576 | 0.342-0.968 | 0.037 | 0.436 | 0.236-0.806 | 0.008 |
| pT of TNM, T1 + T2 vs T3 + T4 | 0.572 | 0.332-0.986 | 0.044 | 0.942 | 0.477-1.861 | 0.863 |
| Lymph node metastasis, positive vs negative | 0.988 | 0.591-1.651 | 0.964 | - - - | - - - | - - - |
| Clinical stage of TNM, III vs I + II | 0.225 | 0.122-0.414 | 0.001 | 0.039 | 0.012-0.124 | 0.001 |
| Pathological differentiation, well/moderate vs poor | 0.440 | 0.258-0.752 | 0.003 | 0.641 | 0.324-1.267 | 0.201 |
| Serum lncRNA MEG3 expression, high vs low | 2.789 | 1.615-4.816 | 0.001 | 0.173 | 0.063-0.480 | 0.002 |
TNM: Tumor node metastasis; lncRNA: Long non-coding RNAs; MEG3: Maternally expressed gene 3; CI: Confidence interval; HR: Hazard ratio.