Table 1.
Correlation between clinicopathological characteristics and serum alanine aminotransferase, alanine aminotransferase, bilirubin, albumin, plasma DNA, or hepatitis B virus DNA levels in the 350 healthy controls and 313 patients
| Group | Number of cases | Serum ALT (U/L) | P | Bilirubin (μM) | P | Plasma DNA (ng/mL) | P | HBV DNA (IU/mL) | P | Serum AST (U/L) | P | Albumin (g/L) | P |
| Healthy controls | 350 | 19.1 (15.1) | 25.5 (17.6) | 0.0 (0.0) | 16.4 (14.3) | 46.0 (22.2) | |||||||
| Sex | < 0.01 | 0.865 | < 0.01 | --- | < 0.01 | 0.062 | |||||||
| Male | 250 | 22.3 (14.1) | 10.6 (5.8) | 30.0 (16.1) | 0.0 (0.0) | 19.6 (14.1) | 46.4 (20.8) | ||||||
| Female | 100 | 12.6 (7.6) | 10.2 (5.5) | 16.7 (8.1) | 0.0 (0.0) | 10.1 (5.5) | 45.5 (20.1) | ||||||
| Age (yr) | 0.819 | 0.833 | 0.056 | --- | 0.916 | 0.066 | |||||||
| < 36 | 175 | 18.9 (17.9) | 9.7 (5.4) | 23.6 (16.4) | 0.0 (0.0) | 16.0 (15.9) | 47.6 (20.3) | ||||||
| ≥ 36 | 175 | 19.8 (13.7) | 10.5 (5.7) | 26.8 (19.3) | 0.0 (0.0) | 16.7 (12.2) | 45.8 (23.4) | ||||||
| HBsAb | 0.263 | 0.439 | 0.060 | --- | 0.549 | 0.884 | |||||||
| Negative | 166 | 18.7 (15.1) | 10.3 (5.6) | 27.3 (19.1) | 0.0 (0.0) | 15.8 (15.1) | 45.7 (22.5) | ||||||
| Positive | 184 | 19.1 (15.0) | 10.3 (5.6) | 24.2 (16.0) | 0.0 (0.0) | 16.5 (15.2) | 46.2 (21.6) | ||||||
| Drinking history | < 0.01 | 0.002 | 0.000 | --- | 0.000 | 0.711 | |||||||
| No | 278 | 18.6 (12.1) | 10.4 (5.7) | 22.8 (15.5) | 0.0 (0.0) | 15.8 (11.1) | 46.1 (20.9) | ||||||
| Yes | 72 | 34.1 (29.2) | 21.0 (19.2) | 38.3 (19.0) | 0.0 (0.0) | 33.5 (27.4) | 45.4 (23.7) | ||||||
| Hepatitis B patients | 313 | 103.3 (118.5) | < 0.011 | 85.6 (77.2) | 0.0001 | 132.9 (253.7) | < 0.011 | 6.1 (2.9) | < 0.011 | 97.0 (101.6) | < 0.011 | 42.7 (31.2) | < 0.011 |
| Sex | 0.972 | 0.606 | 0.772 | 0.149 | 0.656 | 0.761 | |||||||
| Male | 224 | 101.4 (114.4) | 88.3 (91.6) | 134.2 (260.2) | 6.2 (2.7) | 95.3 (99.5) | 42.4 (32.7) | ||||||
| Female | 89 | 113.5 (143.8) | 82.9 (89.1) | 132.2 (170.7) | 5.6 (2.8) | 101.7 (116.6) | 43.0 (33.2) | ||||||
| Age (yr) | 0.011 | 0.221 | 0.312 | < 0.01 | 0.831 | 0.591 | |||||||
| < 36 | 155 | 89.2 (120.0) | 86.3 (90.4) | 135.9 (256.6) | 6.7 (3.0) | 96.5 (98.3) | 42.2 (30.4) | ||||||
| ≥ 36 | 158 | 115.9 (124.9) | 83.9 (91.5) | 115.8 (244.5) | 5.6 (2.6) | 97.8 (103.2) | 43.1 (29.7) | ||||||
| HBeAg | 0.236 | 0.173 | 0.833 | < 0.01 | 0.742 | 0.070 | |||||||
| Negative | 159 | 109.7 (126.6) | 84.4 (89.4) | 126.3 (294.0) | 5.4 (3.1) | 97.7 (101.8) | 43.3 (32.5) | ||||||
| Positive | 154 | 101.4 (117.0) | 86.1 (90.7) | 135.7 (228.9) | 6.5 (2.3) | 97.4 (99.6) | 40.6 (34.6) | ||||||
| Drinking history | 0.487 | 0.577 | 0.574 | 0.200 | 0.433 | 0.654 | |||||||
| No | 187 | 107.0 (122.8) | 85.0 (87.3) | 126.3 (255.4) | 6.2 (2.7) | 95.8 (98.5) | 42.0 (30.8) | ||||||
| Yes | 126 | 100.6 (118.0) | 86.9 (90.3) | 142.8 (243.6) | 6.0 (3.0) | 98.3 (100.1) | 43.2 (30.7) |
1
Compared with the healthy controls. All continuous data are expressed as medians (interquartile range). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HBV: hepatitis B virus; HBsAb: Hepatitis B surface antibody; HBeAg: Hepatitis B E-antigen.