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Effects of metabolism on the pharmacokinetics and pharmacodynamics of small molecules. This figure illustrates how metabolism of a xenobiotic can alter its pharmacodynamics (PD), including pharmacological activity (Act), and toxicological effects (Tox). Moreover, the nature of the resulting metabolites can influence their involvement in pharmacokinetic processes (i.e. ADME absorption, distribution, metabolism, excretion). DETP diethylthiophosphate
