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. 2019 Aug 12;11:116. doi: 10.1186/s13148-019-0715-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Correlation between transcriptional expression and the promoter hypermethylation of tumor suppressor genes in OSCC cell lines. a Summarized results based on the RT-PCR and MSP results of 14 tumor suppressor genes in 10 OSCC cell lines (Ca9-22, HSC4, OSC20, SAS, SCC25, HN22, YD10B, YD38, YD9, and HSC3). The correlation between transcriptional expression and promoter hypermethylation was categorized by the following three criteria: (1) genes are silenced by promoter hypermethylation with re-expression by 5-aza-dC treatment (indicated in yellow), (2) genes are silenced by promoter hypermethylation without re-expression by 5-aza-dC treatment (indicated in blue), and (3) genes are not correlated between gene expression and promoter methylation (indicated in gray). b Methylation frequencies of TSGs in 10 OSCC cell lines by MSP analysis