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. 2019 Jul 22;116(32):15883–15888. doi: 10.1073/pnas.1815678116

Table 1.

Estimated effects of hypothetical air pollutant interventions on asthma incidence rates in the CHS, 1993 to 2014

Air pollutant intervention Asthma incidence rate (95% CI) Absolute incidence rate difference (95% CI) Percentage incidence rate difference (95% CI)
NO2
 Natural course 21.6 (19.6 to 23.3) Reference Reference
 Remain at 1993 levels 25.8 (22.7 to 29.3) 4.2 (1.9 to 6.9) 19.3% (8.9% to 31.6%)
Percentage reduction
 10% 19.4 (17.4 to 21.4) −2.3 (−3.5 to −1.1) −10.5% (−16.0% to −5.2%)
 20% 17.4 (14.9 to 20.0) −4.2 (−6.3 to −2.1) −19.6% (−28.9% to −10.1%)
 30% 15.7 (12.8 to 18.8) −6.0 (−8.6 to −3.1) −27.6% (−39.3% to −14.6%)
Hypothetical standards
 30 ppb 20.1 (18.2 to 22.0) −1.6 (−2.4 to −0.8) −7.3% (−11.2% to −3.5%)
 20 ppb 17.4 (15.2 to 19.9) −4.2 (−5.9 to −2.3) −19.6% (−27.0% to −10.7%)
 10 ppb 13.2 (10.5 to 16.8) −8.5 (−11.0 to −5.0) −39.2% (−50.4% to −23.3%)
PM2.5
 Natural course 21.6 (19.6 to 23.3) Reference Reference
 Remain at 1993 levels 23.7 (20.9 to 26.8) 2.1 (0.2 to 4.4) 9.8% (0.9% to 20.4%)
Percentage reduction
 10% 20.6 (18.6 to 22.7) −1.0 (−1.9 to −0.1) −4.5% (−8.9% to −0.4%)
 20% 19.7 (17.3 to 22.2) −1.9 (−3.6 to −0.2) −8.8% (−16.8% to −0.9%)
 30% 18.9 (16.0 to 21.9) −2.8 (−5.2 to −0.3) −12.8% (−23.9% to −1.3%)
Hypothetical standards
 15 µg/m3 19.2 (16.7 to 21.9) −2.4 (−4.3 to −0.2) −11.0% (−20.1% to −1.2%)
 12 µg/m3 18.4 (15.5 to 21.7) −3.2 (−5.7 to −0.3) −14.9% (−26.5% to −1.6%)
 10 µg/m3 17.8 (14.6 to 21.5) −3.8 (−6.6 to −0.4) −17.6% (−30.7% to −1.9%)

Estimated incidence rates (cases per 1,000 person-years) and 95% CIs based on multilevel Poisson regression models with an offset term for person-time, a random effect for cohort nested within community, and adjusted for community, age, sex, ethnicity, race, presence of gas stove in the home, participation in team sports, and baseline year mean ambient temperature.