Table 5.

Comparison of DEMO domain assembly models with or without experimental data assistance

Domain	Method	TM-score	RMSD, Å	iRMSD, Å	No. of clashes
Starting with experimentally solved domain structures
2dom (N = 166)	DEMO	0.78	7.3	5.5	0.59
	DEMO-CL	0.85	3.6	2.0	0.45
	DEMO-EM	0.89	3.9	2.7	0.23
2dis (N = 81)	DEMO	0.84	5.5	3.8	1.18
	DEMO-CL	0.86	3.7	2.4	1.02
	DEMO-EM	0.92	3.3	2.9	0.62
All (N = 247)	DEMO	0.80	6.7	5.0	0.78
	DEMO-CL	0.85	3.7	2.1	0.64
	DEMO-EM	0.90	3.7	2.8	0.36
Starting with I-TASSER predicted domain models
2dom (N = 116)	DEMO	0.67	9.8	8.0	0.56
	DEMO-CL	0.70	8.0	5.3	1.49
	DEMO-EM	0.72	7.2	6.7	0.60
2dis (N = 41)	DEMO	0.58	12.4	8.9	2.36
	DEMO-CL	0.63	10.8	8.1	2.31
	DEMO-EM	0.66	10.2	8.3	2.45
All (N = 157)	DEMO	0.65	10.5	8.2	1.03
	DEMO-CL	0.68	8.7	6.0	1.70
	DEMO-EM	0.71	8.0	7.1	1.08

Bold indicates the best result in each category. N, number of proteins.