Table 5.
Multivariable Cox analysis for microalbuminuria and cardiovascular endpoints.
| Microalbuminuria number of events = 98 |
Cardiovascular events Number of events = 112 |
|||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| p.Glu936Asp (Rec model) | 3.254 (1.462–7.241) | 0.0038 | 2.683 (1.227–5.868) | 0.0134 |
| ACEi therapy | 0.415 (0.270–0.639) | <0.0001 | 0.716 (0.485–1.055) | 0.0908 |
| Gender (male) | 1.532 (0.913–2.569) | 0.1061 | 1.610 (0.982–2.638) | 0.0589 |
| Smoking habits | 1.401 (0.881–2.226) | 0.1541 | – | – |
| HbA1c† | 5.170 (2.207–12.113) | 0.0002 | 2.892 (1.231–6.797) | 0.0149 |
| UAE† | 9.415 (6.042–14.791) | <0.0001 | 1.742 (1.262–2.404) | 0.0007 |
| Age | – | – | 1.047 (1.020–1.075) | 0.0006 |
| Hypertension duration | – | – | 1.026 (1.003–1.050) | 0.0250 |
| BMI | – | – | 0.940 (0.895–0.986) | 0.0117 |
| Serum Creatinine | – | – | 2.220 (0.595–8.287) | 0.2352 |
| LDL cholesterol | – | – | 1.007 (1.002–1.012) | 0.0112 |
†log transformed. Rec, recessive model; LDL, low-density lipoprotein; BMI, body mass index. P values in bold are statistically significant.