Table 9.
Multivariable Cox analysis for cardiovascular endpoints based on 112 CV events.
| Hba1c fup + MAP fup | Hba1c fup + DBP fup | Hba1c fup + SBP fup | ||||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| p.Glu936Asp* | 2.406 (1.030–5.618) | 0.0425 | 2.412 (1.036-5.618) | 0.0412 | 2.441 (1.046-5.696) | 0.039 |
| ACEi therapy | 0.887 (0.580–1.356) | 0.5789 | 0.863 (0.564–1.320) | 0.4973 | 0.853 (0.562–1.297) | 0.458 |
| Gender (male) | 1.621 (0.932–2.819) | 0.0869 | 1.637 (0.938–2.857) | 0.0826 | 1.700 (0.983–2.943) | 0.058 |
| HbA1c follow up | 1.090 (0.912–1.301) | 0.3436 | 1.091 (0.914–1.303) | 0.335 | 1.093 (0.916–1.304) | 0.325 |
| UAE baseline† | 1.578 (1.109–2.247) | 0.0113 | 1.601 (1.126–2.276) | 0.0087 | 1.549 (1.086–2.208) | 0.0156 |
| Age | 1.048 (1.109–1.078) | 0.0012 | 1.055 (1.025–1.086) | 0.0002 | 1.039 (1.008–1.070) | 0.0121 |
| Hypertension duration | 1.007 (0.979–1.036) | 0.6378 | 1.011 (0.0983–1.039) | 0.454 | 1.007 (0.980–1.036) | 0.615 |
| BMI | 0.924 (0.876–0.975) | 0.0039 | 0.924 (0.875–0.975) | 0.004 | 0.928 (0.880–0.978) | 0.0054 |
| Serum creatinine | 1.760 (0.400–7.740) | 0.454 | 1.680 (0.378–7.466) | 0.4953 | 1.884 (0.431–8.234) | 0.4 |
| LDL cholesterol | 1.008 (1.003–1.014) | 0.0032 | 1.009 (1.003–1.014) | 0.0027 | 1.009 (1.003–1.048) | 0.0026 |
| MAP follow-up | 1.045 (1.010–1.081) | 0.0116 | – – | – | – – | – |
| DBP follow-up | – – | – | 1.040 (1.002–1.081) | 0.0415 | – – | – |
| SBP follow-up | – – | – | – – | – | 1.027 (1.005–1.048) | 0.0142 |
MAP, mean arterial; BMI, body mass index; LDL, low-density lipoprotein. pressure. *recessive model. †Log transformed. P values in bold are statistically significant.