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. 2019 Jul 23;10:1662. doi: 10.3389/fimmu.2019.01662

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Copyright © 2019 Chen, Ma, Liu, Ma, Chen, Lin, Si, Ma and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Responses of the diversity, richness, and structure of the gut microbiota to sham, C. butyricum, and norfloxacin treatment in EAE mice. (A) Genus species phylogeny tree of all three groups. (B) Venn diagram of each group and the number of differences between species are shown. (C) Unweighted Unifrac principal coordinates analysis plots 3D of each sample and the distance of each group are shown. Each sample was collected from three mice (n = 3). (D–H) shows the Observed species index, Shannon index, Chao index, Simpson index, and ACE index of each group. (I–J) Relative abundances of the gut microbiota at phylum level and genus level. Statistically significant data are indicated by asterisks (^*P < 0.05 and ^***P < 0.001). ns, not significant.