Table 3.

Research and clinical use of FTY720/fingolimod.

Disease	Clinical trial	In vitro (reference)	In vivo (reference)
Amyotrophic lateral sclerosis	Phase II	Munoz-Saez et al., 2015	Potenza et al., 2016
Acute stroke	Phase II	Agudo-Lopez et al., 2010; Czubowicz et al., 2015	Czech et al., 2009; Shichita et al., 2009; Zhou et al., 2010; Liesz et al., 2011; Wei et al., 2011; Wacker et al., 2012; Yung et al., 2012; Liu et al., 2013a; Ichijo et al., 2015; Zheng et al., 2015
Schizophrenia	Phase II		Jang et al., 2011; Muhle et al., 2013
Rett syndrome	Phase I	Deogracias et al., 2012	Guy et al., 2001
Glioblastoma	Phase I	Paugh et al., 2009; Estrada-Bernal et al., 2012	Yoshida et al., 2010; Zhang et al., 2015
Alzheimer’s disease		Puglielli et al., 2003	Asle-Rousta et al., 2013a; Hemmati et al., 2013; Asle-Rousta et al., 2014
Huntington’s disease		Di Pardo et al., 2014; Miguez et al., 2015	Di Pardo et al., 2014
Parkinson’s disease		Pyszko and Strosznajder, 2014b; Vargas-Medrano et al., 2014	Komnig et al., 2018
Traumatic brain injury			Zhang et al., 2007; Zhang et al., 2008; Mencl et al., 2014; Novgorodov et al., 2014
Epilepsy			Hodgson et al., 1999; MacLennan et al., 2001; Mikati et al., 2003; Akahoshi et al., 2011; Gao et al., 2012
Pain		Chen et al., 2014	Coste et al., 2008; Doyle et al., 2011; Mair et al., 2011; Zhang et al., 2015
Krabbe’s disease		O’sullivan and Dev, 2015	Contreras et al., 2010