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. 2019 Jul 30;13:347. doi: 10.3389/fncel.2019.00347

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Copyright © 2019 Salt, Hartsock, Hou and Piu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulation of intratympanic applications of triamcinolone-acetonide suspension (A), dexamethasone suspension (B), and triamcinolone suspension (C) to the human ear. Entry and elimination kinetics are based on perilymph measurements in guinea pigs. ST elimination half-times were 12, 44, and 700 min for triamcinolone-acetonide, dexamethasone, and triamcinolone, respectively. Triamcinolone-acetonide and dexamethasone only distribute apically to a limited degree before reaching a steady state, unlike triamcinolone which reaches the cochlear apex.