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. 2019 Jul 30;9:586. doi: 10.3389/fonc.2019.00586

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Copyright © 2019 Yuan, Xu, Zhang, Kong, Wu, Lao, Zhou, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The combination of trametinib with bosutinib synergistically reduced the viability of NSCLC in vitro. (A) H1650, (B) HCC827, and (C) HCC827 ER cell lines were seeded in 96-well plates. Trametinib, bosutinib, or their combination was added for 24 h. Cell viability was determined using the MTT assay. (D) H1650, (E) HCC827, and (F) HCC827 ER cell lines were seeded at specific cell densities in six-well plates and were incubated overnight. The cells were treated with different concentrations of trametinib, bosutinib, or their combination for 24 h. Then, the media were replaced with complete medium without drugs, and the cells were cultured for 14 days. Histograms of quantitative analysis of the colony formation assay: (G) H1650, (H) HCC827, and (I) HCC827ER cell lines. The data are presented as mean ± S.D. ^*P < 0.05, ^***P < 0.001.