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PANS1 acts independently of SGOs. (A–D) Chromosome spreads in sgo1 sgo2 pans1 male meiosis. (A) Diakinesis. No defect is detected; five bivalents are observed. (B–D) Metaphases I, with five bivalents (B), almost complete loss of cohesion (C), or complete loss of cohesion leading to 20 free chromatids (D). (E and F) Chromosome spreads in sgo1 sgo2 pDMC1::PANS1ΔD male meiosis. (E) Metaphase I with stretched bivalents. (F) Aberrant metaphase II with bivalents. (Scale bars, 10 µm.)
